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The scientists identified that a receptor identified as Cxcr4, when blocked in mice, decreased the tendency of Body fat stem cells to produce into white Body fat, also known as white adipose tissue. This therapy could probably be coupled with minimal doses of estrogen therapy to chop improvements in body Unwanted fat distribution in menopausal women and defend against cardiometabolic condition.
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The staff made use of an engineered mouse that allowed them to delete Cxcr4 in this adipose lineage, thereby removing the receptor.
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“Whenever we deleted Cxcr4 we discovered which the stem cells have been much less dedicated to the adipose lineage in female mice, and so they appeared to be hypersensitive to estrogen therapies,” Berry reported.
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